Improving the Outcome of Bone Marrow Transplantation by Using CD52 Monoclonal Antibodies to Prevent Graft-Versus-Host Disease and Graft Rejection
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چکیده
منابع مشابه
Improving the outcome of bone marrow transplantation by using CD52 monoclonal antibodies to prevent graft-versus-host disease and graft rejection.
Graft-versus-host disease (GVHD) is a major cause of mortality and morbidity after allogeneic bone marrow transplantation, but can be avoided by removing T lymphocytes from the donor bone marrow. However, T-cell depletion increases the risk of graft rejection. This study examined the use of CD52 monoclonal antibodies to eliminate T cells from both donor marrow and recipient to prevent both GVHD...
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Allogeneic bone marrow transplantation is a curative treatment for leukemia and lymphoma, but graft-vs-host disease (GVHD) remains a major complication. Using a GVHD protective nonmyeloablative conditioning regimen of total lymphoid irradiation and antithymocyte serum (TLI/ATS) in mice that has been recently adapted to clinical studies, we show that regulatory host NKT cells prevent the expansi...
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Gribben JG, Freedman AS, Neuberg D, et al. Immunologic purging of marrowassessed by PCRbefore autologous bone marrowtransplantation for B-cell lymphoma. N Engl J Med 325: 1525, 1991. HamonMD, Prentice HG, Gottlieb DJ, et al. Immunotherapy with interleukin 2 after ABMTin AML.Bone Marrow Transplant ll: 399, 1993. Yanai N, Sekine C, Yagita H, Obinata M, Roles for integrin vary late activation anti...
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ژورنال
عنوان ژورنال: Blood
سال: 1998
ISSN: 1528-0020,0006-4971
DOI: 10.1182/blood.v92.12.4581